Pharmacokinetics and tissue depletion of tilmicosin in turkeys.

Pathological changes in turkeys experimentally infected with different doses of A/ostrich/Italy/984/2000 H7N1 avian influenza virus

Following experimental inoculation of 3-week-old turkeys with different titres (106, 104, 103, 102 and 101 egg infectious dose (EID50)) of A/ostrich/Italy/984/2000 H7N1 highly pathogenic avian influenza virus (HPAIV), the selected tissues and organs were examined for pathological changes. Tissue samples from different organs that obtained from dead and sacrificed birds were fixed in 10% neutral...

Pharmacokinetics and Pulmonary Disposition of Clarithromycin and Tilmicosin in Foals

Milk and Blood Pharmacokinetics of Tylosin and Tilmicosin following Parenteral Administrations to Cows

The aim of this study is to determine the pharmacokinetics of tylosin and tilmicosin in serum and milk in healthy Holstein breed cows (n = 12) and reevaluate the amount of residue in milk. Following the intramuscular administration of tylosin, the maximum concentrations (C max) in serum and milk were found to be 1.30 ± 0.24 and 4.55 ± 0.23 µg/mL, the time required to reach the peak concentratio...

Pharmacokinetics and bioavailability of three promising tilmicosin-loaded lipid nanoparticles in comparison with tilmicosin phosphate following oral administration in broiler chickens

Ali RASSOULI*, Alwan AL-QUSHAWI, Fatemeh ATYABI, Seyed Mostafa PEIGHAMBARI, Mehdi ESFANDYARI-MANESH, Gholam Reza SHAMS Department of Pharmacology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Department of Avian Diseases, Faculty of Veterinary Medicine, University of Tehra...

Pharmacokinetics and Efficacy of Tilmicosin in the Treatment of Pasteurella haemolytica Bronchopneumonia in Calves

Tilmicosin was administered intravenously and subcutaneously at a dose rate of 10 mg/kg bwt to determine its concentration in blood and bronchial secretion as well as its kinetic behavior in healthy and Pasteurella haemolytica type A1-infected calves. Sever acute bronchopneumonia was induced in 10 calves by inoculating them intra-tracheally with P. haemolytica type A1. The calves were treated w...